A triazole linkage that mimics the DNA phosphodiester group in living systems
نویسندگان
چکیده
منابع مشابه
A triazole linkage that mimics the DNA phosphodiester group in living systems.
We describe the development of a chemical process based on the CuAAC reaction (click chemistry) to ligate DNA strands and produce an unnatural triazole backbone linkage. The chemical reaction is templated by a complementary DNA splint which accelerates the reaction and provides the required specificity. The resultant 1,4-triazole linkage is read through by DNA and RNA polymerases and is biocomp...
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ژورنال
عنوان ژورنال: Quarterly Reviews of Biophysics
سال: 2015
ISSN: 0033-5835,1469-8994
DOI: 10.1017/s0033583515000141